BK Life Sciences, Seoul National University
Department of Nuclear Medicine, Seoul National University College of Medicine
Department of Biomedical Engineering, Hanyang University College of Medicine
Department of Radiology, Seoul National University College of Medicine
Department of Psychiatry, Seoul National University College of Medicine & Neuroscience Institute, SNU-MRC, Korea
Correspondence: Profesor Jun Soo Kwon, Department of Psychiatry and BK Life Sciences, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul, Korea 110-744
Declaration of interest This study was supported by the Korean Research Foundation (1998-003-F00172).
Background Although a number of functional imaging studies are in agreement in suggesting orbitofrontal and subcortical hyperfunction in the pathophysiology of obsessivecompulsive disorder (OCD), the structural findings have been contradictory.
Aims To investigate grey matter abnormalities in patients with OCD by employing a novel voxel-based analysis of magnetic resonance images.
Method Statistical parametric mapping was utilised to compare segmented grey matter images from 25 patients with OCD with those from 25 matched controls.
Results Increased regional grey matter density was found in multiple cortical areas, including the left orbitofrontal cortex, and in subcortical areas, including the thalamus. On the other hand, regions of reduction were confined to posterior parts of the brain, such as the left cuneus and the left cerebellum.
Conclusions Increased grey matter density of frontalsubcortical circuits, consonant with the hypermetabolic findings from functional imaging studies, seems to exist in patients with OCD, and cerebellar dysfunction may be involved in the pathophysiology of OCD.
Related articles in BJP:
This article has been cited by other articles:
![]() |
J. Radua and D. Mataix-Cols Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder The British Journal of Psychiatry, November 1, 2009; 195(5): 393 - 402. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. A. van den Heuvel, P. L. Remijnse, D. Mataix-Cols, H. Vrenken, H. J. Groenewegen, H. B. M. Uylings, A. J. L. M. van Balkom, and D. J. Veltman The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems Brain, April 1, 2009; 132(4): 853 - 868. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. D. Huey, R. Zahn, F. Krueger, J. Moll, D. Kapogiannis, E. M. Wassermann, and J. Grafman A Psychological and Neuroanatomical Model of Obsessive-Compulsive Disorder J Neuropsychiatry Clin Neurosci, November 1, 2008; 20(4): 390 - 408. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. R. Szeszko, C. Christian, F. MacMaster, T. Lencz, Y. Mirza, S. P. Taormina, P. Easter, M. Rose, G.A. Michalopoulou, and D. R. Rosenberg Gray Matter Structural Alterations in Psychotropic Drug-Naive Pediatric Obsessive-Compulsive Disorder: An Optimized Voxel-Based Morphometry Study Am J Psychiatry, October 1, 2008; 165(10): 1299 - 1307. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Menzies, G. B. Williams, S. R. Chamberlain, C. Ooi, N. Fineberg, J. Suckling, B. J. Sahakian, T. W. Robbins, and E. T. Bullmore White Matter Abnormalities in Patients With Obsessive-Compulsive Disorder and Their First-Degree Relatives Am J Psychiatry, October 1, 2008; 165(10): 1308 - 1315. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. R. Chamberlain, L. A. Menzies, N. A. Fineberg, N. del Campo, J. Suckling, K. Craig, U. Muller, T. W. Robbins, E. T. Bullmore, and B. J. Sahakian Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study The British Journal of Psychiatry, September 1, 2008; 193(3): 216 - 221. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Woolley, I. Heyman, M. Brammer, I. Frampton, P. K. McGuire, and K. Rubia Brain activation in paediatric obsessive compulsive disorder during tasks of inhibitory control The British Journal of Psychiatry, January 1, 2008; 192(1): 25 - 31. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Menzies, S. Achard, S. R. Chamberlain, N. Fineberg, C.-H. Chen, N. del Campo, B. J. Sahakian, T. W. Robbins, and E. Bullmore Neurocognitive endophenotypes of obsessive-compulsive disorder Brain, December 1, 2007; 130(12): 3223 - 3236. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. L. Remijnse, M. M. A. Nielen, A. J. L. M. van Balkom, D. C. Cath, P. van Oppen, H. B. M. Uylings, and D. J. Veltman Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder. Arch Gen Psychiatry, November 1, 2006; 63(11): 1225 - 1236. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Mirza, J. O'Neill, E. A. Smith, A. Russell, J. M. Smith, S. P. Banerjee, R. Bhandari, C. Boyd, M. Rose, J. Ivey, et al. Increased Medial Thalamic Creatine-Phosphocreatine Found by Proton Magnetic Resonance Spectroscopy in Children With Obsessive-Compulsive Disorder Versus Major Depression and Healthy Controls J Child Neurol, February 1, 2006; 21(2): 106 - 111. [Abstract] [PDF] |
||||
![]() |
D.-H. Kang, J.-J. Kim, J.-S. Choi, Y. I. Kim, C.-W. Kim, T. Youn, M. H. Han, K.-H. Chang, and J. S. Kwon Volumetric Investigation of the Frontal-Subcortical Circuitry in Patients With Obsessive-Compulsive Disorder J Neuropsychiatry Clin Neurosci, August 1, 2004; 16(3): 342 - 349. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Pujol, C. Soriano-Mas, P. Alonso, N. Cardoner, J. M. Menchon, J. Deus, and J. Vallejo Mapping Structural Brain Alterations in Obsessive-Compulsive Disorder Arch Gen Psychiatry, July 1, 2004; 61(7): 720 - 730. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Saxena, A. L. Brody, K. M. Maidment, E. C. Smith, N. Zohrabi, E. Katz, S. K. Baker, and L. R. Baxter Jr. Cerebral Glucose Metabolism in Obsessive-Compulsive Hoarding Am J Psychiatry, June 1, 2004; 161(6): 1038 - 1048. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. R. Szeszko, S. MacMillan, M. McMeniman, S. Chen, K. Baribault, K. O. Lim, J. Ivey, M. Rose, S. P. Banerjee, R. Bhandari, et al. Brain Structural Abnormalities in Psychotropic Drug-Naive Pediatric Patients With Obsessive-Compulsive Disorder Am J Psychiatry, June 1, 2004; 161(6): 1049 - 1056. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. L. Hoffman, M. Hornig, K. Yaddanapudi, O. Jabado, and W. I. Lipkin A Murine Model for Neuropsychiatric Disorders Associated with Group A {beta}-Hemolytic Streptococcal Infection J. Neurosci., February 18, 2004; 24(7): 1780 - 1791. [Abstract] [Full Text] [PDF] |
||||
![]() |
J S Kwon, Y-W Shin, C-W Kim, Y I Kim, T Youn, M H Han, K-H Chang, and J-J Kim Similarity and disparity of obsessive-compulsive disorder and schizophrenia in MR volumetric abnormalities of the hippocampus-amygdala complex J. Neurol. Neurosurg. Psychiatry, July 1, 2003; 74(7): 962 - 964. [Abstract] [Full Text] [PDF] |
||||