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Antidepressant use in clinical practice: efficacy v. effectiveness

School of Pharmacy and Chemistry, Liverpool John Moores University, Liverpool, UK

TIMOTHY R. HYLAN, PhD

CNS Medical Service Liaison Team, Pfizer, Inc., USA

Correspondence: Mr John Donoghue, PCS Health, 4 Wrenfield Grove, Liverpool L17 9QD, UK. Tel: +44 151 726 1860; e-mail: john{at}donoghue.u-net.com

Declaration of interest J.D. received an honorarium and travel expenses from Eli Lilly & Co. At the time of manuscript preparation, T.R.H. was employed at Eli Lilly & Co.

Background Although the efficacy of antidepressants has been demonstrated in randomised, controlled clinical trials, it is how an antidepressant is used in clinical practice that determines its clinical effectiveness, or real-world efficacy.

Aims To explore the frequency with which antidepressants are used at adequate dose and duration to obtain remission of symptoms and prevent relapse in clinical practice and discuss potential implications for clinical outcomes.

Method Studies of antidepressant prescribing were reviewed and comparisons made between antidepressant classes and individual compounds within those classes.

Results Naturalistic studies show that patients who begin therapy on tricyclic antidepressants often receive sub-therapeutic doses for inadequate duration; conversely, patients who begin therapy on selective serotonin reuptake inhibitors more often receive an adequate dose of therapy for a longer duration.

Conclusions How antidepressants are used in clinical practice can determine the clinical outcomes that are achieved. Antidepressants that are more forgiving of sub-optimal prescribing and use patterns by providers and patients, respectively, may help to improve real-world efficacy.