© 2001 The Royal College of Psychiatrists
Signs of asphyxia at birth and risk of schizophrenia
,
Population-based case—control study
Community Medicine, Unit for Psychosis Research, Stockholm, Sweden
University of Wales College of Medicine, Cardiff
Institute of Psychiatry and GKT School of Medicine, London
Sachsska Children's Hospital, Stockholm, Sweden
University of Wales College of Medicine, Cardiff
Department of Social Medicine, Göteborg University, Sweden
Correspondence: Christina Dalman, MD, Community Medicine, Unit for Psychosis Research, PO Box 175 33, S-118 91 Stockholm, Sweden. E-mail: christina.dalman{at}smd.sll.se
Declaration of interest No conflict of interest. The study was supported by the Stanley Foundation, the Swedish Medical Research Council and the Söderberg-Königska Foundation.
See invited commentaries, pp.
415–416, this issue.
See pp. 409–414, this
issue.
Background Previous research has found an association between obstetric complications and schizophrenia, but in many studies the sample size was limited, and no assessment of specific exposures was possible.
Aims To assess the role of different complications, and in particular to distinguish between disordered foetal development and hypoxia at birth.
Method From the Stockholm County In-Patient Register and community registers, we identified 524 cases of schizophrenia and 1043 controls, matched for age, gender, hospital and parish of birth. Data on obstetric complications were obtained from birth records.
Results There was a strong association between signs of asphyxia at birth and schizophrenia (OR 4.4; 95% C11.9-10.3) after adjustment for other obstetric complications, maternal history of psychotic illness and social class.
Conclusions Signs of asphyxia at birth are associated with an increased risk of schizophrenia in adults.
Related articles in BJP:
- Highlights of this issue
- ELIZABETH WALSH
BJP 2001 179: 0.[Full Text] - Obstetric complications and risk of schizophrenia: Effect of gender, age at diagnosis and maternal history of psychosis
- HOLLIE V. THOMAS, CHRISTINA DALMAN, ANTHONY S. DAVID, JOHAN GENTZ, GLYN LEWIS, and PETER ALLEBECK
BJP 2001 179: 409-414.[Abstract] [Full Text] - Invited commentaries on: Signs of asphyxia at birth and risk of schizophrenia/Obstetric complications and risk of schizophrenia
- T.J. Crow
BJP 2001 179: 415-416.[Full Text] - Invited commentaries on: Signs of asphyxia at birth and risk of schizophrenia/Obstetric complications and risk of schizophrenia
- A. M. McIntosh and S. M. Lawrie
BJP 2001 179: 416.[Full Text]
This article has been cited by other articles:
 |
|
 |
|
  B. J. Insel, C. A. Schaefer, I. W. McKeague, E. S. Susser, and A. S. Brown Maternal Iron Deficiency and the Risk of Schizophrenia in Offspring Arch Gen Psychiatry, October 1, 2008; 65(10): 1136 - 1144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Brown, T. Bottiglieri, C. A. Schaefer, C. P. Quesenberry Jr, L. Liu, M. Bresnahan, and E. S. Susser Elevated Prenatal Homocysteine Levels as a Risk Factor for Schizophrenia Arch Gen Psychiatry, January 1, 2007; 64(1): 31 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Clarke, M. Harley, and M. Cannon The Role of Obstetric Events in Schizophrenia Schizophr Bull, January 1, 2006; 32(1): 3 - 8. [Full Text] [PDF]
|
|
|
|
 |
|
 A S David and M Prince Psychosis following head injury: a critical review J. Neurol. Neurosurg. Psychiatry, March 1, 2005; 76(suppl_1): i53 - i60. [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Jablensky, V. Morgan, S. R. Zubrick, C. Bower, and L.-A. Yellachich Pregnancy, Delivery, and Neonatal Complications in a Population Cohort of Women With Schizophrenia and Major Affective Disorders Am J Psychiatry, January 1, 2005; 162(1): 79 - 91. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sipos, F. Rasmussen, G. Harrison, P. Tynelius, G. Lewis, D. A Leon, and D. Gunnell Paternal age and schizophrenia: a population based cohort study BMJ, November 6, 2004; 329(7474): 1070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hack, E. A. Youngstrom, L. Cartar, M. Schluchter, H. G. Taylor, D. Flannery, N. Klein, and E. Borawski Behavioral Outcomes and Evidence of Psychopathology Among Very Low Birth Weight Infants at Age 20 Years Pediatrics, October 1, 2004; 114(4): 932 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gunnell, F. Rasmussen, D. Fouskakis, P. Tynelius, and G. Harrison Patterns of Fetal and Childhood Growth and the Development of Psychosis in Young Males: A Cohort Study Am. J. Epidemiol., August 15, 2003; 158(4): 291 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.J. CROW Obstetric Complications and Schizophrenia Am J Psychiatry, May 1, 2003; 160(5): 1011 - 1012. [Full Text]
|
|
|
|
 |
|
 G. Lewis, P. Allebeck, A. S. David, C. Dalman, J Gentz, and H. V. Thomas Asphyxia at birth and schizophrenia The British Journal of Psychiatry, May 1, 2002; 180(5): 465 - 465. [Full Text] [PDF]
|
|
|
|
|
|
H. V. THOMAS, C. DALMAN, A. S. DAVID, J. GENTZ, G. LEWIS, and P. ALLEBECK Obstetric complications and risk of schizophrenia: Effect of gender, age at diagnosis and maternal history of psychosis The British Journal of Psychiatry, November 1, 2001; 179(5): 409 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.J. Crow Invited commentaries on: Signs of asphyxia at birth and risk of schizophrenia/Obstetric complications and risk of schizophrenia The British Journal of Psychiatry, November 1, 2001; 179(5): 415 - 416. [Full Text] [PDF]
|
|
|
|
|
|
A. M. McIntosh and S. M. Lawrie Invited commentaries on: Signs of asphyxia at birth and risk of schizophrenia/Obstetric complications and risk of schizophrenia The British Journal of Psychiatry, November 1, 2001; 179(5): 416 - 416. [Full Text]
|
|