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The British Journal of Psychiatry (2002) 180: 39-44
© 2002 The Royal College of Psychiatrists

Region-specific changes in phospholipid metabolism in chronic, medicated schizophrenia

31P-MRS study at 4.0 Tesla

J. ERIC JENSEN, BSc, YOUSEF M. AL-SEMAAN, MD and PETER C. WILLIAMSON, MD

RICHARD W.J. NEUFELD, PhD

University of Western Ontario, London, Ontario, Canada

RAVI S. MENON, PhD

Roberts Research Institute, London, Ontario, Canada

BETSY SCHAEFFER, BSc

University of Western Ontario, London, Ontario, Canada

MARIA DENSMORE, BSc and DICK J. DROST, PhD

St Joseph's Health Centre, London, Ontario, Canada

Correspondence: Professor P.C.Williamson, Department of Psychiatry, London Health Science Centre, University Campus, Rm IONI5, London, Ontario, Canada N6A 5A5

Declaration of interest This work was funded by the Canadian Institute of Health Research Grant MT-1078.

Background Membrane phospholipid abnormalities in people with schizophrenia, measured with 31P magnetic resonance spectroscopy (31P-MRS), have been previously reported in brain regions involved in this disorder.

Aims In this 4.0 Tesla 31P-MRS study of people with schizophrenia, membrane phospholipid metabolism was examined in brain regions previously inaccessible due to their small volumes.

Method Three-dimensional chemical-shift imaging (3D—CSI) examined 15 cc volumes in 12 brain regions in 11 people with chronic schizophrenia and 11 healthy control volunteers.

Results Glycerophosphoethanolamine was decreased in the anterior cingulate, right prefrontal cortex and left thalamus, but increased in the left hippocampus and cerebellum in those with schizophrenia. Phosphoethanolamine and glycerophosphocholine were decreased in the right prefrontal region and phosphocholine was decreased in the anterior cingulate. No significant difference in membrane phospholipid levels existed between groups in the parieto-occipital and posterior cingulate regions.

Conclusions Altered membrane phospholipid metabolism was demonstrated in all regions implicated in schizophrenia.




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