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The British Journal of Psychiatry (2002) 180: 135-139
© 2002 The Royal College of Psychiatrists

OLD AGE PSYCHIATRY PAPERS

New drugs for Alzheimer's disease and other dementias{dagger}

ROGER BULLOCK, MRCPsych

Department of Old Age Psychiatry and Kingshill Research Centre, Avon and Wiltshire Mental Health Trust, Victoria Hospital, Swindon SNI 4HZ, UK. Tel: +44 (0)1 793 437501; Fax: +44 (0)1 793 437521

Correspondence: e-mail: roger.bullock{at}kingshill-research.org

Declaration of interest R.B. has worked on clinical trials in dementia for all the major pharmaceutical companies.

{dagger} See editorial, pp. 97–98, this issue.

ABSTRACT

Background Alzheimer's disease management involves symptomatic drug treatments passed by the National Institute for Clinical Excellence. Disease modification is now the goal.

Aims To review current and developmental drugs for Alzheimer's disease, their usage, and the clinical context of known facts and proposed specific models.

Method A brief evidence-based review was made, using literature where available, or evidence from consensus groups where it was absent.

Results There is good evidence to support the use of cholinesterase inhibitors, and perhaps vitamin E. Oestrogen and anti-inflammatory agents show possibility, but there is not enough evidence to support routine use.

Conclusions Symptomatic treatments exist for Alzheimer's disease. Observational studies and increasing knowledge of brain biology are leading towards further treatment options. Old age psychiatrists have valuable treatments they now have to learn to use.


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BJP 2002 180: 97-98. [Full Text]  



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