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The British Journal of Psychiatry (2002) 180: 140-143
© 2002 The Royal College of Psychiatrists

OLD AGE PSYCHIATRY PAPERS

Frontotemporal dementia{dagger}

JULIE S. SNOWDEN, PhD

DAVID NEARY, MD and DAVID M. A. MANN, PhD

Greater Manchester Neuroscience Centre, Hope Hospital, Salford, UK

Correspondence: Dr Julie Snowden, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Hope Hospital, Salford M6 8 HD, UK. Tel: +44 (0) 161 787 2561; +44 (0) 161 787 2993; e-mail: julie.snowden{at}man.ac.uk

Declaration of interest None.

{dagger} See editorial, pp. 97–98, this issue.

ABSTRACT

Background Frontotemporal dementia accounts for up to 20% of cases of dementia in the presenium, yet remains poorly recognised. Diagnostic criteria have been devised to aid clinical diagnosis.

Aims To provide an overview of clinical and pathological characteristics of frontotemporal dementia and its nosological status.

Methods The review summarises consensus diagnostic criteria for frontotemporal dementia and draws on the authors' clinical experience of 300 frontotemporal dementia cases, and pathological experience of 50 autopsied cases.

Results Frontotemporal dementia is characterised by pronounced changes in affect and personal and social conduct. Some patients also develop motor neuron disease. Mutations in the tau gene account for some but not all familial cases of frontotemporal dementia.

Conclusions Frontotemporal dementia is a focal form of dementia, which is clinically and pathologically distinct from other dementias. It represents an important model for understanding the functions of the frontotemporal lobes.


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