Skip to main page content

• HOME
• Current
• Archive
• Feedback
• Subscribe
• Help

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by MILLER, P. Articles by JOHNSTONE, E. C. Search for Related Content PubMed PubMed Citation Articles by MILLER, P. Articles by JOHNSTONE, E. C.

Schizotypal components in people at high risk of developing schizophrenia: early findings from the Edinburgh High-Risk Study

MAJELLA BYRNE, MSc, ANN HODGES, MRCPsych, STEPHEN M. LAWRIE, MRCPsych, DAVID G. CUNNINGHAM OWENS, FRCPsych and EVE C. JOHNSTONE, FRCPsych

Department of Psychiatry, University of Edinburgh

Correspondence: Dr P. Miller, Department of Psychiatry, University of Edinburgh, Morningside Park, Edinburgh EH10 5HF, UK. Tel: 0131-537-6680; Fax: 0131-537-6531; e-mail: Pmmill{at}srvl.med.ed.ac.uk

Declaration of interest None.

Background The study of high-risk groups and the development of schizophrenia.

Aims To investigate further schizotypy, measured by the Structured Interview for Schizotypy (SIS), and to examine relationships between schizotypal components, psychotic symptoms on the Present State Examination (PSE) and subsequent schizophrenia.

Method The SIS and PSE were administered on entry. Schizophrenia onsets were recorded during follow-up.

Results The SIS yielded four principal components labelled social withdrawal, psychotic symptoms, socio-emotional dysfunction and odd behaviour. On entry, these differentiated between controls, subjects at risk for schizophrenia with and without symptoms and patients with schizophrenia. Seven of 78 subjects at risk developed schizophrenia within 39 months. This was best predicted by combining the four SIS components.

Conclusions Schizotypy is heterogeneous and may become psychosis, particularly if several of its components are present. As psychosis develops, odd behaviour gives way to psychotic symptoms and social function deteriorates.

This article has been cited by other articles:

				L. C. Emmerson, S. L. Miller, and J. J. Blanchard Behavioral Signs of Schizoidia and Schizotypy in the Biological Parents of Social Anhedonics Behav Modif, July 1, 2009; 33(4): 452 - 473. [Abstract] [PDF]

				E. C. Johnstone, D. G. C. Owens, P. Hoare, S. Gaur, M. D. Spencer, J. Harris, A. W Stanfield, V. Moffat, N. Brearley, P. Miller, et al. Schizotypal cognitions as a predictor of psychopathology in adolescents with mild intellectual impairment The British Journal of Psychiatry, December 1, 2007; 191(6): 484 - 492. [Abstract] [Full Text] [PDF]

				S. J. GLATT, W. S. STONE, S. V. FARAONE, L. J. SEIDMAN, and M. T. TSUANG Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia The British Journal of Psychiatry, October 1, 2006; 189(4): 337 - 345. [Abstract] [Full Text] [PDF]

				Z. Delawalla, D. M. Barch, J. L. Fisher Eastep, E. S. Thomason, M. J. Hanewinkel, P. A. Thompson, and J. G. Csernansky Factors Mediating Cognitive Deficits and Psychopathology Among Siblings of Individuals With Schizophrenia Schizophr Bull, July 1, 2006; 32(3): 525 - 537. [Abstract] [Full Text] [PDF]

				M. S. KESHAVAN, G. BERGER, R. B. ZIPURSKY, S. J. WOOD, and C. PANTELIS Neurobiology of early psychosis The British Journal of Psychiatry, August 1, 2005; 187(48): s8 - s18. [Abstract] [Full Text] [PDF]

				E. C. Johnstone, K. P. Ebmeier, P. Miller, D. G. C. Owens, and S. M. Lawrie Predicting schizophrenia: findings from the Edinburgh High-Risk Study The British Journal of Psychiatry, January 1, 2005; 186(1): 18 - 25. [Abstract] [Full Text] [PDF]