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The British Journal of Psychiatry (2002) 180: 339-344
© 2002 The Royal College of Psychiatrists

Evidence for non-progressive changes in adolescent-onset schizophrenia

Follow-up magnetic resonance imaging study

A. C. D. JAMES, MRCPsych

Highfield Adolescent Unit, Warneford Hospital, Oxford

A. JAVALOYES, MRCPsych

Unidad de Salud Mental Infantil, Centro de Salud Hospital Provincial, Alicante, Spain

S. JAMES, DCR

Highfield Adolescent Unit, Warneford Hospital, Oxford

D. M. SMITH, PhD

Centre for Statistics in Medicine, Institute of Health Sciences, Headington, Oxford

Correspondence: A. C. D. James, Highfield Adolescent Unit, Warneford Hospital, Warneford Lane, Headington, Oxford OX3 7JX, UK

Declaration of interest Funding provided by Oxfordshire Regional Health Authority and SANE.

Background It is not clear how far brain abnormalities in early-onset schizophrenia result from progressive neurodevelopmental or neurodegenerative processes.

Aims To investigate the hypothesis that structural brain abnormalities in adolescent-onset schizophrenia are progressive in the early phase of the illness.

Method A magnetic resonance imaging case—control study of 16 adolescents with schizophrenia (mean age 16.6 years, s.d.=1.9 years) with a mean time of 2.7 years (s.d.=1.7 years) between measurements and 16 matched controls (average age 16.0 years, s.d.=2.0 years) with a mean time of 1.7 years (s.d.=0.5 years) between measurements.

Results There was no evidence of progressive structural brain changes during late adolescence. Significant ventricular enlargement (greater in males) and left-sided temporal lobe changes were evident from the outset of the illness.

Conclusions Neurodevelopmental brain abnormalities are non-progressive during late adolescence.


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