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The British Journal of Psychiatry (2002) 181: 138-143
© 2002 The Royal College of Psychiatrists

Temporal lobe volume changes in people at high risk of schizophrenia with psychotic symptoms

STEPHEN M. LAWRIE, MRCPsych, HEATHER C. WHALLEY, MSc, SUHEIB S. ABUKMEIL, MRCPsych, JULIA N. KESTELMAN, BSc, PATRICK MILLER, PhD, JONATHAN J. K. BEST, FRCR, DAVID G. C. OWENS, FRCPsych and EVE C. JOHNSTONE, FRCPsych

University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, UK

Correspondence: Dr Stephen M. Lawrie, University Department of Psychiatry, Morningside Park, Edinburgh EH10 5HF, UK. Tel: 0131 537 6671; fax: 0131 537 6531; e-mail: s.lawrie{at}ed.ac.uk

Declaration of interest None.

Background Magnetic resonance imaging (MRI) has demonstrated abnormalities of brain structure, particularly of the temporal lobes, in schizophrenia. These are thought to be neurodevelopmental in origin, but when they become evident is unknown.

Aims To determine if temporal lobe volumes reduce during the development of symptoms of schizophrenia in initially well people at high risk of this disorder.

Method A group of 66 people who had at least two first- or second-degree relatives with schizophrenia and a control group of 20 healthy people had a structural MRI scan of the whole brain which was repeated after approximately 2 years. Regions of interest, specifically the amygdala—hippocampus complex and the temporal lobes, were traced semi-automatically by three masked raters with good inter-and intrarater reliability.

Results Regional brain volume changes over 2 years did not differ between high-risk and healthy participants. Within the high-risk group, the 19 people with psychotic symptoms (12 at first assessment) had a mean reduction of 2163 mm3 in the right temporal lobe compared with 97 mm3 in the 47 without symptoms (P=0.02).

Conclusions Our findings suggest that people at high risk of schizophrenia with psychotic symptoms show reductions in temporal lobe volumes.


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