This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Related articles in BJP
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by HOLLIS, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HOLLIS, C.
The British Journal of Psychiatry (2003) 182: 37-44
© 2003 The Royal College of Psychiatrists

Developmental precursors of child- and adolescent-onset schizophrenia and affective psychoses: diagnostic specificity and continuity with symptom dimensions

CHRIS HOLLIS, MRCPsych

Section of Developmental Psychiatry, Division of Psychiatry, University of Nottingham, E Floor, South Block, Queen's Medical Centre, Nottingham NG7 2UH, UK.

Correspondence: Tel/fax: 0115 970 9946; e-mail: Chris.hollis{at}nottingham.ac.uk

Declaration of interest C.H. was funded by the Medical Research Council.

Background An increased rate of premorbid impairment has been reported in both child- and adolescent-onset schizophrenic and affective psychoses.

Aims To examine the evidence for a specific association between premorbid impairment and child- and adolescent-onset schizophrenia, and whether specific continuities exist between premorbid impairments and psychotic symptom dimensions.

Method Retrospective case note study of 110 first-episode child- and adolescent-onset psychoses (age 10-17 years). DSM—III—R diagnoses derived from the OPCRIT algorithm showed 61 with schizophrenia (mean age 14.1 years) and 49 with other non-schizophrenic psychoses (mean age 14.7 years).

Results Premorbid social impairment was more common in early-onset schizophrenia than in other early-onset psychoses (OR 1.9, P=0.03). Overall, impaired premorbid development, enuresis and incontinence during psychosis were specifically associated with the negative psychotic symptom dimension.

Conclusions Premorbid social impairments are more marked in child-and adolescent-onset schizophrenia than in other psychoses. There appears to be developmental continuity from premorbid impairment to negative symptoms.


Related articles in BJP:

Highlights of this issue
ELIZABETH WALSH
BJP 2003 182: 1-a2. [Full Text]  

Psychiatry in pictures
ROBERT HOWARD
BJP 2003 182: 1-a3. [Full Text]  



This article has been cited by other articles:


Home page
 BrainHome page
T. M. Hyde, A. Deep-Soboslay, B. Iglesias, J. H. Callicott, J. M. Gold, A. Meyer-Lindenberg, R. A. Honea, L. B. Bigelow, M. F. Egan, E. M. Emsellem, et al.
Enuresis as a premorbid developmental marker of schizophrenia
Brain, September 1, 2008; 131(9): 2489 - 2498.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
M. Walshe, M. Taylor, K. Schulze, E. Bramon, S. Frangou, D. Stahl, E. Kravariti, E. Daly, P. Fearon, R. M. Murray, et al.
Familial liability to schizophrenia and premorbid adjustment
The British Journal of Psychiatry, September 1, 2007; 191(3): 260 - 261.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
L. BOEING, V. MURRAY, A. PELOSI, R. McCABE, D. BLACKWOOD, and R. WRATE
Adolescent-onset psychosis: prevalence, needs and service provision
The British Journal of Psychiatry, January 1, 2007; 190(1): 18 - 26.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
H. Trotman, A. McMillan, and E. Walker
Cognitive Function and Symptoms in Adolescents with Schizotypal Personality Disorder
Schizophr Bull, July 1, 2006; 32(3): 489 - 497.
[Abstract] [Full Text] [PDF]