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Exposure therapy and sertraline in social phobia: I-year follow-up of a randomised controlled trial

Haukeland University Hospital, Bergen

SVEIN BLOMHOFF, MD

National Hospital, Oslo, Norway

KERSTIN HELLSTRØM, DrMedSci

Ulleråker University Hospital, Uppsala, Sweden

INGAR HOLME, PhD

Ullevål University Hospital, Norway

MATS HUMBLE, MD

Huddinge University Hospital, Sweden

HANS PETTER MADSBU, MD

Elverum Medical Center, Elverum

JAN EGIL WOLD, MD

Innherred Hospital, Levanger, Norway

Correspondence: Tone Tangen Haug, Haukeland University Hospital, 0021 Bergen, Norway

Declaration of interest Funding was provided by Pfizer, Inc.

Background Maintenance of treatment effect is important for the choice of treatment for social phobia.

Aims To examine the effect of exposure therapy and sertraline 28 weeks after cessation of medical treatment.

Method In this study 375 patients with social phobia were randomised to treatment with sertraline or placebo for 24 weeks, with or without the addition of exposure therapy. Fifty-two weeks after inclusion, 328 patients were evaluated by the same psychometric tests as at baseline and the end of treatment (24 weeks).

Results The exposure therapy group and the placebo group had a further improvement in scores on social phobia during follow-up: mean change in the Clinical Global Impression — Social Phobia overall severity score was 0.45 (95% CI 0.16-0.65, P < 0.01) for the exposure group, and 0.25 (95% CI 0.00-0.48, P < 0.05) for the placebo group. At week 52 the sertraline plus exposure group and the sertraline-alone group had a significant deterioration on the 36-item Short Form Health Survey compared with exposure alone.

Conclusions Exposure therapy alone yielded a further improvement during follow-up, whereas exposure therapy combined with sertraline and sertraline alone showed a tendency towards deterioration after the completion of treatment.

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