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Neural response to emotional prosody in schizophrenia and in bipolar affective disorder

School of Psychology, University of Reading, and Neuroscience and Emotion Section, Institute of Psychiatry, London

Rebecca Elliott, PhD

Neuroscience and Psychiatry Unit, University of Manchester

Martin Barry, MPhil and Alan Cruttenden, PhD

Department of Linguistics, University of Manchester

Peter W. R. Woodruff, PhD, MRCP, MRCPsych

SCANLab, Academic Department of Psychiatry, University of Sheffield

Correspondence: Dr Rachel Mitchell, School of Psychology, University of Reading, Whiteknights Road, Reading, Berkshire RG6 6AL, UK

Declaration of interest R.M. received a studentship from Neuraxis¹, and funding from the Neuroscience and Psychiatry Unit, University of Manchester.

¹ Formerly a contract research organisation devoted to the investigation of central nervous system drugs and their activity; now subsumed within Medeval (www.medeval.com).

Background Evidence suggests a reversal of the normal left-lateralised response to speech in schizophrenia.

Aims To test the brain’s response to emotional prosody in schizophrenia and bipolar disorder.

Method BOLD contrast functional magnetic resonance imaging of subjects while they passively listened or attended to sentences that differed in emotional prosody.

Results Patients with schizophrenia exhibited normal right-lateralisation of the passive response to ‘pure’ emotional prosody and relative left-lateralisation of the response to unfiltered emotional prosody. When attending to emotional prosody, patients with schizophrenia activated the left insula more than healthy controls. When listening passively, patients with bipolar disorder demonstrated less activation of the bilateral superior temporal gyri in response to pure emotional prosody, and greater activation of the left superior temporal gyrus in response to unfiltered emotional prosody. In both passive experiments, the patient groups activated different lateral temporal lobe regions.

Conclusions Patients with schizophrenia and bipolar disorder may display some left-lateralisation of the normal right-lateralised temporal lobe response to emotional prosody.

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