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The British Journal of Psychiatry (2004) 184: 446-447
© 2004 The Royal College of Psychiatrists

SHORT REPORTS

Prematurity at birth and adolescent depressive disorder

George C. Patton, MD FRANCP, Carolyn Coffey, MSc, John B. Carlin, PhD and Craig A. Olsson, PhD

Murdoch Children's Research Institute

Ruth Morley, PhD

Department of Paediatrics, University of Melbourne, Australia

Correspondence: Professor George Patton, Centre for Adolescent Health, Murdoch Children's Research Institute, 2 Gatehouse Street, Parkville 3052, Victoria, Australia. E-mail: george.patton{at}rch.org.rch.org.au

Declaration of interest None.

ABSTRACT

Association between prematurity/low birthweight and adolescent depressive disorder studied using a case–control design within a prospective cohort study of 2032 adolescents. Odds for depressive disorder were 11-fold (95% CI 2–62) higher for the premature/low-birthweight participants after regression adjustment for major confounding factors. For premature/low-birthweight females, cumulative rates of depressive disorder over 30 months were 15.2% (95% CI 11.1–20.5) v. 1.8% (95% CI 1.6–2.1) in those with normal deliveries. Physiological adaptations in utero before full term may be implicated causally in some cases of depression in adolescence.


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