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Vascular disease/risk and late-life depression in a Korean community population

Department of Psychiatry,College of Medicine, Chosun University, Kwangju, Korea

ROBERT STEWART, MRCPsych

Section of Epidemiology, Institute of Psychiatry, London

IL-SEON SHIN, PhD

Department of Psychiatry & Research Institute of Medical Science, Chonnam National University Medical School, Kwangju, Korea

JIN-SANG YOON, PhD

Department of Psychiatry & Research Institute of Medical Science, Chonnam National University Medical School, Kwangju, Korea

Correspondence: Professor Jin-Sang Yoon, Department of Psychiatry, Chonnam University Medical School, 5 Hak-dong, Dong-Ku, Kwangju, 501-757, Republic of Korea. Tel: +82 62 220 6142; Fax: +82 62 225 2351; e-mail: jsyoon{at}chonnam.ac.kr

Declaration of interest Funded by the Ministry of Health and Welfare of Korea and Janssen Korea Limited.

Background Associations between vascular risk factors and late-life depression are controversial.

Aims To investigate the association between measures of vascular disease/risk and depression and confounding and effect modification by APOE genotype and cognitive function.

Method In a Korean community population aged 65+ (n=732), diagnosis of depression (Geriatric Mental State Schedule) and information on vascular status, disability, APOE genotype and cognitive function were obtained.

Results Previous stroke and lower high-densitylipoprotein cholesterol level (but neither hypertension nor diabetes) were significantly associated with depression (independently of disability and cognitive function). These associations were stronger in participants with borderline cognitive impairment, although not to a significant extent.

Conclusions Except for previous stroke and an atherogenic lipid profile, associations between depression and other common risk factors for cerebrovascular disease were not evident.

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