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The British Journal of Psychiatry (2004) 185: 258-259
© 2004 The Royal College of Psychiatrists

SHORT REPORTS

Cell density and cortical thickness in Heschl’s gyrus in schizophrenia, major depression and bipolar disorder

David Cotter, MD, PhD

Department of Psychiatry, Education and Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland

Daniel Mackay, MSc

Department of Neuroscience, Institute of Psychiatry

Sophia Frangou, MD, PhD

Section of the Neurobiology of Psychosis, Institute of Psychiatry

Lance Hudson, MSc

Department of Neuroscience, Institute of Psychiatry

Sabine Landau, PhD

Department of Biostatistics, Institute of Psychiatry, London, UK

Correspondence: Dr David R. Cotter, Beaumont Hospital, Dublin 9, Ireland. Tel: +353 1 809 3740; fax: +353 1 809 3741; e-mail: drcotter{at}rcsi.ie

Declaration of interest None. Funding detailed in Acknowledgements.

ABSTRACT

There is evidence that the superior temporal gyrus and Heschl’s gyrus within it are implicated in schizophrenia. We investigated neuronal and glial cell density and cortical thickness within Heschl’s gyrus, using the optical disector to estimate cell density within cortical layers 3 and 5 in tissue derived postmortem from people with diagnoses of major depressive disorder, schizophrenia and bipolar disorder, compared with normal controls (n=15 per group). No significant difference in neuronal or glial cell density or in cortical thickness was observed between the groups; our findings therefore provide no support for the presence of cellular pathology within Heschl’s gyrus in schizophrenia.


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