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The British Journal of Psychiatry (2004) 185: 516-517
© 2004 The Royal College of Psychiatrists

SHORT REPORTS

Temporal course of auditory hallucinations

Sukhwinder S. Shergill, MRCPsych PhD, Mick J. Brammer, PhD, Edson Amaro, MD PhD, Steve C. R. Williams, PhD, Robin M. Murray, FRCPsych, DSc and Phillip K. McGuire, MD PhD

Division of Psychological Medicine, Institute of Psychiatry, London, UK

Correspondence: Dr Sukhwinder S. Shergill, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK. Tel: 020 7848 0350; fax: 020 7848 0350; e-mail: s.shergill{at}iop.kcl.ac.uk

Declaration of interest None.

S.S.S. and E.A. were supported by the Wellcome Trust. S.S.S. received funding from the National Alliance for Research on Schizophrenia and Depression.

ABSTRACT

Summary We used functional magnetic resonance imaging to examine how brain activity associated with auditory verbal hallucinations in schizophrenia changed during hallucinatory events. Activation in the left inferior frontal and right middle temporal gyri was evident 6–9 s before the person signalled the onset of the hallucination, whereas activation in the bilateral temporal gyri and the left insula coincided with the perception of the hallucination. This supports the hypothesis that during hallucinations activation in cortical regions mediating the generation of inner speech may precede the engagement of areas implicated in the perception of auditory verbal material.




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