© 2005 The Royal College of Psychiatrists
Cognitive–behavioural therapy for refractory psychotic symptoms of schizophrenia resistant to atypical antipsychotic medication
Randomised controlled trial
Department of Psychological Medicine, Institute of Psychiatry, London, UK and Department of Psychiatry and Neuropsychiatry, Maastricht University, The Netherlands
Parnassia Institute, The Hague and University of Groningen, The Netherlands
Academic Division of Clinical Psychology, School of Psychiatry and Behavioural Sciences, University of Manchester, UK
University of Groningen and Department of Psychotic Disorders, GGZ-Drenthe, Assen, The Netherlands
Correspondence: Lucia R.Valmaggia, Department of Psychological Medicine, PO 67, Institute of Psychiatry, De Crespigny Park, London SE5 SE5 8AF, UK.Tel/fax: +44(0)220 7848 0952; e-mail: L.Valmaggia{at}iop.kcl.ac.uk
Declaration of interest None. Funding detailed in Acknowledgements.
Background There is increasing evidence that cognitive–behavioural therapy can be an effective intervention for patients experiencing drug-refractory positive symptoms of schizophrenia.
Aims To investigate the effects of cognitive–behavioural therapy on in-patients with treatment-refractory psychotic symptoms.
Method Manualised therapy was compared with supportive counselling in a randomised controlled study. Both interventions were delivered by experienced psychologists over 16 sessions oftreatment. Therapy fidelity was assessed by two independent raters. Participants underwent masked assessment at baseline, after treatment and at 6 months’ follow-up. Main outcome measures were the Positive and Negative Syndrome Scale and the Psychotic Symptoms Rating Scale. The analysis was by intention to treat.
Results Participants receiving cognitive cognitive–behavioural therapy had improved with regard to auditory hallucinations and illness insight at the post-treatment assessment, but these findings were not maintained at follow-up.
Conclusions Cognitive–behavioural therapy showed modest short-term benefits over supportive counselling for treatment-refractory positive symptoms of schizophrenia.
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