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Predictors of outcome following treatment for chronic fatigue

Guy’s, King’s and St Thomas’ School of Medicine, London, UK

Correspondence: Lucy Darbishire, Department of General Practice and Primary Care, Guy’s, King’s and St Thomas’ School ol of Medicine, 5 Lambeth Walk, London, SE11 6SP, UK. E-mail: lucy.clark@kcl.ac.uk

Declaration of interest None. Funding detailed in Acknowledgements.

We explored the role of baseline characteristics of 105 patients who presented with fatigue in primary care in determining outcome following either graded exercise or cognitive–behavioural therapy. Meeting the criteria for chronic fatigue syndrome was the most powerful predictor of poor outcome and this negative effect was enhanced by greater functional impairment or greater perceived negative consequences, but was not further enhanced by both.