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The Danish National Schizophrenia Project: prospective, comparative longitudinal treatment study of first-episode psychosis

Centre of Psychiatry Glostrup, Copenhagen University

Kristian Valbak, PhD

Psychiatric University Hospital, Aarhus

Susanne Harder, PhD

Department of Psychology University of Copenhagen

Per Knudsen, Senior Psychologist

Amager Hospital, Department of Psychiatry, Copenhagen University

Anne Køster, MD

Sct Hans Hospital, Roskilde

Matilde Lajer, MD

Psychiatric Hospital South, County of South Jutland

Anne Lindhardt, PhD

State University Hospital, Department of Psychiatry, Copenhagen

Gerda Winther, private practising psychologist

Copenhagen

Lone Petersen, Clinical Psychologist

Bispebjerg Hospital, Department of Psychiatry, Copenhagen University, Copenhagen

Per Jørgensen, MDSc

Psychiatric University Hospital, Aarhus

Merete Nordentoft, PhD

Bispebjerg Hospital, Department of Psychiatry, Copenhagen

Anne Helms Andreasen, MS

Research Centre for Prevention and Health, Copenhagen County, Denmark

Correspondence: Associate Research Professor Bent Rosenbaum, Centre of Psychiatry Glostrup, Unit for Psychotherapy, Education and Research, University of Copenhagen, Ndr.Ringvej, DK-2600 Glostrup, Denmark.Tel: (45) 4323 3401; fax: (45) 4323 3987; e-mail: bros{at}glostruphosp.kbhamt.dk

Declaration of interest None.

Background First-episode psychosis intervention may improve the course and outcome of schizophrenic disorders.

Aims To describe the Danish National Schizophrenia Project and to measure the outcome of two different forms of intervention after 1 year, compared with standard treatment.

Method A prospective, prospective, longitudinal, multicentre investigation included 562 patients, consecutively referred over a 2-year period, with a first episode of psychosis. Patients were allocated to supportive psychodynamic psychotherapy as a supplement to treatment as usual, an integrated, assertive, psychosocial and educational treatment programme or treatment as usual.

Results There was a non-significant tendency towards greater improvement in social functioning in the integrated treatment group and the supportive psychodynamic psychotherapy group compared with the treatment as usual group. Significance was reached for some measures when the confounding effect of drug and alcohol misuse was included.

Conclusions Integrated treatment and supportive psychodynamic psychotherapy in addition to treatment as usual may improve outcome after 1 year of treatment for people with first-episode psychosis, compared with treatment as usual alone.

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