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The British Journal of Psychiatry (2005) 187: 55-61
© 2005 The Royal College of Psychiatrists

Modafinil modulates anterior cingulate function in chronic schizophrenia

SEAN A. SPENCE, MRCPsych and RUSSELL D. GREEN, MBChB

Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield

IAIN D. WILKINSON, PhD

Academic Unit of Radiology, University of Sheffield

MIKE D. HUNTER, MRCPsych

SCANLab, Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, Sheffield, UK

Correspondence: Dr Sean A. Spence, Sheffield Cognition and Neuroimaging (SCANLab), Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK. Tel: +44 (0) 114 22 61519; Fax: +44 (0) 114 22 61522; E-mail: s.a.spence{at}sheffield.ac.uk

Declaration of interest This study was supported by an investigator-led award (to S.A.S.) from Cephalon (UK). M.D.H. is supported by the Wellcome Trust (UK).

Background Schizophrenia is associated with widespread cognitive deficits that have an impact on social function. Modafinil promotes wakefulness and is reported to enhance cognition.

Aims To study the acute effects of modafinil administration upon brain activity and cognitive performance in people with chronic schizophrenia.

Method In a randomised double-blind placebo-controlled crossover design, 19 patients received either modafinil (100 mg) or placebo prior to undertaking a working memory task with functional magnetic resonance imaging.

Results Seventeen patients completed the study and another underwent acute relapse 4 days post-drug. Modafinil administration was associated with significantly greater activation in the anterior cingulate cortex during the working memory task. The anterior cingulate cortex signal correlated with cognitive performance, although only a subset of patients exhibited `enhancement'.

Conclusions Modafinil modulates anterior cingulate cortex function in chronic schizophrenia but its beneficial cognitive effects may be restricted to a subset of patients requiring further characterisation.




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