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The British Journal of Psychiatry (2005) 187: 103-105
© 2005 The Royal College of Psychiatrists

EDITORIALS

Unravelling the complexity of attention-deficit hyperactivity disorder: a behavioural genomic approach*

PHILIP ASHERSON, MRCPsych, PhD

MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK

JONNA KUNTSI, BSc, PhD and ERIC TAYLOR, FRCPsych, FRCP, PhD

MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK

Correspondence: Professor Philip Asherson, MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. E-mail: p.asherson{at}iop.kcl.ac.uk

Declaration of interest The authors' research is funded by the Medical Research Council, the Wellcome Trust and the US National Institute of Health. P.A. has given research talks at meetings sponsored by Janssen-Cilag and Eli Lilly.

* This is one of a series of editorials being published in the Journal to mark the 10th anniversary of the Social, Genetic and Developmental Psychiatry Centre at the Institute of Psychiatry.

ABSTRACT

International research has established that there is a strong genetically inherited contribution to attention-deficit hyperactivity disorder (ADHD) and the genetic mechanisms involved are being sought with considerable success. It is now established that certain alleles of the genes coding for the dopamine D4 receptor and the dopamine transporter occur more frequently in children with ADHD than in healthy controls, and we are finding other DNA changes associated with ADHD. A major challenge for the field now is to clarify how genetic susceptibility is translated into disorder by integrating the fields of quantitative and molecular genetics, neuropsychology and environmental risks.


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