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The British Journal of Psychiatry (2005) 187: 284-285
© 2005 The Royal College of Psychiatrists

SHORT REPORTS

Cognitive performance in presumed obligate carriers for psychosis

Timothea Toulopoulou, PhD, Francesca Mapua-Filbey, PhD, Seema Quraishi, MSc and Eugenia Kravariti, PhD

Division of Psychological Medicine, Institute of Psychiatry, London, UK

Robin G. Morris, PhD

Department of Psychology, Institute of Psychiatry, London, UK

Colm McDonald, MRCPsych, Muriel Walshe, BA, Elvira Bramon, MD and Robin M. Murray, MD

Division of Psychological Medicine, Institute of Psychiatry, London, UK

Correspondence: Dr Timothea Toulopoulou, Section of General Psychiatry, Box 63, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. Tel: +44 (0) 207 848 0061; fax: +44 (0) 207 701 9044; e-mail: t.toulopoulou{at}iop.kcl.ac.uk

Declaration of interest None.

Funding detailed in Acknowledgements.

We report cognitive performance of a group of individuals who are likely to have transmitted liability to psychosis to their offspring. Out of 230 relatives of patients with psychosis, 27 met our criteria for a presumed obligate carrier, that is a non-psychotic individual who had a parent or a sibling as well as an offspring with psychosis. The presumed obligate carriers showed impairments in verbal memory and in visuospatial manipulations, suggesting that these individuals transmit vulnerability for psychosis to their offspring in terms of a disability to recall verbal information and an impaired capacity to perceive spatial relations.


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