The British Journal of Psychiatry (2006) 188: 199-201. doi: 10.1192/bjp.bp.105.020644
© 2006 The Royal College of Psychiatrists
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EDITORIALS

Stressful life events, 5-HTT genotype and risk of depression{dagger}

STANLEY ZAMMIT, PhD, MRCPsych

Department of Psychological Medicine, Cardiff University and Division of Psychiatry, University of Bristol

MICHAEL J. OWEN, PhD, FRCPsych

Department of Psychological Medicine, Cardiff University, Cardiff, UK

Correspondence: Dr Stanley Zammit, Department of Psychological Medicine, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, UK. Fax: +44 (0)29 2074 7839; e-mail: zammits{at}cardiff.ac.uk

Declaration of interest M.J.O. is a consultantto GlaxoSmith Kline and has received honoraria for academic talks from Eli Lilly, AstraZeneca and GlaxoSmith Kline.

{dagger} See pp. 210–215, this issue.

Studies of how genetic and environmental exposures interact may be essential for understanding the aetiology of complex psychiatric disorders. In this issue of the Journal an Australian study reports evidence of such an interaction on risk of depression. We discuss findings in this field in the context of the limitations inherent in studies of gene–environment interactions.


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