The British Journal of Psychiatry (2006) 188: 303-304. doi: 10.1192/bjp.188.4.303
© 2006 The Royal College of Psychiatrists
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EDITORIALS

Patient preference randomised controlled trials in mental health research

LOUISE HOWARD, PhD, MRCP, MRCPsych and GRAHAM THORNICROFT, PhD, FRCPsych, FMedSci

Health Services Research Department, Institute of Psychiatry, King’s College London, London, UK

Correspondence: Dr Louise Howard, PO Box 29, Health Services Research Department, Institute of Psychiatry, King’s College London, London, De Crespigny Park, London SE5 8AF, UK. E-mail: l.howard{at}iop.kcl.ac.uk

Declaration of interest None.

The relationship between psychiatric patients’preferences for differenttreatments and the outcome of interventions is unclear, as the few relevanttrials have tended to be underpowered. Strong patient preferences result in patients refusing to enter a trial. This leads to bias and limits generalisability, and the patient preference randomised controlled trial (RCT) design has been proposed as an alternative. Limitations and advantages of patient preference RCTs are discussed.


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