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Chromosomal abnormalities and psychosis

Division of Psychiatry

BENJAMIN S. PICKARD, PhD

Medical Genetics Section

DOUGLAS H. R. BLACKWOOD, PhD, FRCPE, FRCPsych

Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, UK

Correspondence: Dr Walter J. Muir, Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK. E-mail: walter.muir{at}ed.ac.uk

Declaration of Interest None.

Funding detailed in Acknowledgements.

The search for susceptibility genes for schizophrenia and severe affective disorder has been enhanced by the study of cytogenetic abnormalities that disrupt genes directly. One such gene is DISCI and there is increasing evidence that it may be an important modulator of riskof psychosis.

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