The British Journal of Psychiatry (2006) 189: 81-82. doi: 10.1192/bjp.bp.105.011098
© 2006 The Royal College of Psychiatrists
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SHORT REPORTS

Magnetic resonance imaging abnormalities in young euthymic patients with bipolar affective disorder

Selim M. El-Badri, MD, David A. Cousins, MRCP, MRCPsych, Sean Parker, MRCP and Heather C. Ashton, FRCP

Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne

Victor L. McAllister, FRCR

Department of Neuroradiology, Newcastle General Hospital

I. Nicol Ferrier, MD, FRCP, FRCPsych and P. Brian Moore, PhD, FRCPsych

Department of Psychiatry, University of Newcastle upon Tyne, UK

Correspondence: Dr P. B. Moore, Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. Email: P.B.Moore{at}ncl.ac.uk

Declaration of interest None.

Support from Stanley Medical Research, Bethesda, MD, USA.

Temporal lobe and limbic structures may be abnormalin bipolar disorder. T2-weighted magnetic resonance imaging (MRI) scans frequently show deep white matter lesions. MRI was performed on 50 young (19-39 years) euthymic patients with bipolar disorder and 26 controls. Mean temporal lobe volumes were reduced in patients (right, 9.42 cm3; left, 6.33 cm3) but this could not but this could not be ascribed to a specific structure. Deep white matter lesions were present in 5 patients but no controls raising questions of their aetiological significance.


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