The British Journal of Psychiatry (2006) 189: 229-234. doi: 10.1192/bjp.bp.105.017236
© 2006 The Royal College of Psychiatrists
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Related articles in BJP
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Wade, D.
Right arrow Articles by McGorry, P. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wade, D.
Right arrow Articles by McGorry, P. D.

Substance misuse in first-episode psychosis: 15-month prospective follow-up study*

D. Wade, MA

ORYGEN Youth Health and Department of Psychiatry, University of Melbourne, Parkville, Victoria

S. Harrigan, MSc

ORYGEN Research Centre and Department of Psychiatry, University of Melbourne, Parkville, Victoria

J. Edwards, PhD

ORYGEN Youth Health and Department of Psychiatry, University of Melbourne, Parkville, Victoria

P. M. Burgess, PhD

School of Population Health, University of Queensland, Queensland Centre for Mental Health Research, Richlands, Queensland

G. Whelan, MD

Department of Medicine, University of Melbourne at St Vincent's Hospital, Fitzroy, Victoria

P. D. McGorry, MD

ORYGEN Youth Health, ORYGEN Research Centre and Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia

Correspondence: Darryl Wade, ORYGEN Youth Health, Locked Bag 10, Parkville 3052, Australia. Email: dwade{at}unimelb.edu.au

Declaration of interest None.

* The results of this paper were presented in part at the 4th International Early Psychosis Conference, Vancouver, Canada, 28 September to 1 October, 2004.

Background Well-designed prospective studies of substance misuse in first-episode psychosis can improve our understanding of the risks associated with comorbid substance misuse and psychosis.

Aims To examine the potential effects of substance misuse on in-patient admission and remission and relapse of positive symptoms in first-episode psychosis.

Method The study was a prospective 15-month follow-up investigation of 103 patients with first-episode psychosis recruited from three mental health services.

Results Substance misuse was independently associated with increased risk of in-patient admission, relapse of positive symptoms and shorter time to relapse of positive symptoms after controlling for potential confounding factors. Substance misuse was not associated with remission or time to remission of positive symptoms. Heavy substance misuse was associated with increased riskof in-patient admission, relapse and shorter time to relapse.

Conclusions Substance misuse is an independent risk factor for a problematic recovery from first-episode psychosis.


Related articles in BJP:

From the Editor's desk
Peter Tyrer
BJP 2006 189: 294. [Full Text]  

Highlights of this issue
Sukhwinder S. Shergill
BJP 2006 189: A9. [Full Text]  



This article has been cited by other articles:


Home page
 Br. J. PsychiatryHome page
A. Turkington, C. C. Mulholland, T. M. Rushe, R. Anderson, R. McCaul, S. L. Barrett, R. S. Barr, and S. J. Cooper
Impact of persistent substance misuse on 1-year outcome in first-episode psychosis
The British Journal of Psychiatry, September 1, 2009; 195(3): 242 - 248.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
S. Zammit, T. H. M. Moore, A. Lingford-Hughes, T. R. E. Barnes, P. B. Jones, M. Burke, and G. Lewis
Effects of cannabis use on outcomes of psychotic disorders: systematic review
The British Journal of Psychiatry, November 1, 2008; 193(5): 357 - 363.
[Abstract] [Full Text] [PDF]

Home page
 J PsychopharmacolHome page
J. M.A. Sinclair, A. H. Latifi, and A. W. Latifi
Co-morbid substance misuse in psychiatric patients: prevalence and association with length of inpatient stay
J Psychopharmacol, January 1, 2008; 22(1): 92 - 99.
[Abstract] [PDF]

Home page
 Schizophr BullHome page
S. Archie, B. R. Rush, N. Akhtar-Danesh, R. Norman, A. Malla, P. Roy, and R. B. Zipursky
Substance Use and Abuse in First-Episode Psychosis: Prevalence Before and After Early Intervention
Schizophr Bull, November 1, 2007; 33(6): 1354 - 1363.
[Abstract] [Full Text] [PDF]

Home page
 Evid. Based Ment. HealthHome page
A. Malla
Remission one year after emergency admission is higher for substance-induced psychosis than primary psychosis
Evid. Based Ment. Health, May 1, 2007; 10(2): 41 - 41.
[Full Text] [PDF]