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SHORT REPORTS |
Rudolf Magnus Institute of Neurosciences, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
Correspondence: Dr Wiepke Cahn, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 GX Utrecht, The Netherlands. Tel: 00 31 30 250 8180; fax: 00 31 30 250 5443; email: wcahn{at}umcutrecht.nl
Progressive brain volume changes have been reported in first-episode schizophrenia, but their relationship to the disease process or to other factors remains unclear. We examined such changes in the first year of illness, and related them to 5-year outcome. Progressive brain volume changes, in particular of grey matter, during the first year of illness were found to be significantly associated with clinical and functional outcome 5 years after the first episode. These findings suggest that early dynamic brain volume changes are related to the disease process and predict the longer-term outcome of schizophrenia.
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