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The British Journal of Psychiatry (2006) 189: 381-382. doi: 10.1192/bjp.bp.105.015701
© 2006 The Royal College of Psychiatrists
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SHORT REPORTS

Brain volume changes in the first year of illness and 5-year outcome of schizophrenia

W. CAHN, MD, PhD, N. E. M. van HAREN, PhD, H. E. HULSHOFF POL, PhD, H. G. SCHNACK, PhD, E. CASPERS, MSc, D. A. J. LAPONDER, MSc and R. S. KAHN, MD, PhD

Rudolf Magnus Institute of Neurosciences, Department of Psychiatry, University Medical Center Utrecht, The Netherlands

Correspondence: Dr Wiepke Cahn, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 GX Utrecht, The Netherlands. Tel: 00 31 30 250 8180; fax: 00 31 30 250 5443; email: wcahn{at}umcutrecht.nl

Declaration of interest None.

Progressive brain volume changes have been reported in first-episode schizophrenia, but their relationship to the disease process or to other factors remains unclear. We examined such changes in the first year of illness, and related them to 5-year outcome. Progressive brain volume changes, in particular of grey matter, during the first year of illness were found to be significantly associated with clinical and functional outcome 5 years after the first episode. These findings suggest that early dynamic brain volume changes are related to the disease process and predict the longer-term outcome of schizophrenia.




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