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The British Journal of Psychiatry (2006) 189: 399-404. doi: 10.1192/bjp.bp.105.014779
© 2006 The Royal College of Psychiatrists
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Progression of mild cognitive impairment to dementia: a challenge to current thinking*

ANJA BUSSE, DPsych, MATTHIAS C. ANGERMEYER, MD and STEFFI G. RIEDEL-HELLER, MD, MPH

Leipzig Longitudinal Study of the Aged LEILA75+, Department of Psychiatry, University of Leipzig, Germany

Correspondence: Professor Steffi G. Riedel-Heller, MPH, Department of Psychiatry, University of Leipzig, Johannisallee 20, 04317 Leipzig, Germany. Tel.: +49 341 97 24 530; fax: +49 341 97 24 539. Email: ries{at}medizin.uni-leipzig.de

Declaration of interest None. Funding detailed in Acknowledgements.

* Results of the Leipzig Longitudinal Study of the Aged (LEILA75+)

Background Studies of conversion from mild cognitive impairment to dementia suggest a linear progression over time. Conversion rates during lifetime may extend to 80–90%.

Aims This study examines the time-dependent evolution from mild cognitive impairment to dementia. Current assumptions regarding yearly and lifetime conversion rates are challenged.

Method A community sample of 1045 dementia-free individuals aged 75 years and over was examined by neuropsychological testing based on 6 years of observation.

Results Approximately 60–65% of people with mild cognitive impairment develop clinical dementia during their life. Progression from mild cognitive impairment to dementia appears to be time dependent, occurring primarily within the initial 18 months.

Conclusions Further long-term studies are needed to examine the time-dependent evolution from mild cognitive impairment to dementia and to establish age-specific conversion rates during lifetime.


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