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Modafinil and unconstrained motor activity in schizophrenia

Double-blind crossover placebo-controlled trial

Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, University of Sheffield, UK

Correspondence: Dr Tom F. D. Farrow, SCANLab, Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Northern General Hospital, Norwood Grange Drive, Sheffield S5 7JT, UK. Email: t.f.farrow{at}sheffield.ac.uk

Declaration of interest This study was funded by a grant awarded to S.A.S. by Cephalon UK, the manufacturers of modafinil. The sponsor was involved in the study design, but had no role in data collection, analysis, the writing of the reportor the decision to submit the paper for publication.

Avolition affects quality of life in chronic schizophrenia. We investigated the effect of modafinil upon unconstrained motor activity in 18 male patients. In a randomised crossover design study, wrist-worn actigraphic monitors were used to objectively record motor activity over a 20 h period. Patients’ total activity was significantly greater when given the drug. These data suggest that modafinil increases quantifiable motor behaviour in schizophrenia and may have an impact on avolition.

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