The British Journal of Psychiatry (2006) 189: 463-464. doi: 10.1192/bjp.bp.105.020552
© 2006 The Royal College of Psychiatrists
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SHORT REPORTS

Neuropsychological performance at the age of 13 years and adult schizophreniform disorder*

Prospective birth cohort study

MARY CANNON, MRCPsych, PhD

Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland

TERRIE E. MOFFITT, PhD and AVSHALOM CASPI, PhD

Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Kings’ College London

ROBIN M. MURRAY, MRCPsych, MD, DSc

Division of Psychological Medicine, Institute of Psychiatry, King’s College London, UK

HONALEE HARRINGTON, BSc

Department of Psychology, University of Wisconsin, Madison, Wisconsin, USA

RICHIE POULTON, PhD

Dunedin School of Medicine, University of Otago, Dunedin, New Zealand

Correspondence: Professor Terrie E. Moffitt, Box P080, SDGP Research Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. Email: t.moffitt{at}iop.kcl.ac.uk

Declaration of interest None. Funding detailed in Acknowledgements.

* Presented at the International Congress of Schizophrenia Research, Savannah Georgia, 2–6 April 2005.

We examined neuropsychological functioning at age 13 years in adolescents who later developed schizophreniform disorder, compared with healthy controls and with adolescents diagnosed as having had a manic episode or depression or anxiety disorder. Participants were from an unselected birth cohort. Attentional, executive and motor impairments at age 13 were found in those who later fulfilled diagnostic criteria for schizophreniform disorder, suggesting that these impairments may be the earliest emerging neuropsychological impairments in schizophrenia-related disorders.


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