The British Journal of Psychiatry (2006) 189: 558-559. doi: 10.1192/bjp.bp.105.017087
© 2006 The Royal College of Psychiatrists
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SHORT REPORTS

Delayed early proprioceptive information processing in schizophrenia

SIDSE MARIE ARNFRED, MD, PhD

Department of Psychiatry, University Hospital of Copenhagen, Denmark

RALF P. HEMMINGSEN, MD, MSc

Department of Psychiatry, Bispebjerg Hospital, University Hospital of Copenhagen, Denmark

JOSEF PARNAS, MD, MSc

Department of Psychiatry, Hvidovre Hospital, University Hospital of Copenhagen, Denmark.

Correspondence: Dr Sidse Marie Arnfred, Department of Psychiatry, Hvidovre Hospital,University Hospital of Copenhagen, Brøndbyøstervej 160, 2605 Brøndby, Denmark. Tel.: +45 36 32 38 18; fax: +45 36 32 39 74. Email: s.arnfred{at}tdcadsl.dk or Sidse.Arnfred{at}hh.hosp.dk

Declaration of interests Funding from the Lundbeck Foundation, the A.P.Møller and Chastine Mc-Kinney Møller Foundation,Butcher Max and Inger Wørzner’sTrust,Eli Lilly’s Psychiatric Research Foundation, the Danish Research Council and the Danish Hospital Foundation for Medical Research,Region of Copenhagen, the Faroe Islands and Greenland.

It was first suggested that disordered proprioception was a core feature of schizophrenia by Sandor Rado in 1953. Using a recently designed proprioceptive event-related potential paradigm based on a change of load, we studied 12 unmedicated male out-patients with schizophrenia and 24 controls. In the patients, the early contralateral parietal activity was delayed and later central activity had increased amplitude, but gating was unaffected. The results could be understood within the‘deficiency of corollary discharge’model of schizophrenia but not within the‘filtering’ theory. Further studies, including psychiatric controls, are necessary to verify the specificity of the abnormality.




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