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Processing facial emotions in adults with velo-cardio-facial syndrome: functional magnetic resonance imaging

Department of Psychological Medicine, Institute of Psychiatry, London, UK and Department of Psychiatry, Academic Medical Centre, Amsterdam, The Netherlands

NICOLE SCHMITZ, PhD

Department of Psychological Medicine, Institute of Psychiatry, London, and Department of Radiology, Leiden University Medical Centre, The Netherlands

EILEEN DALY, BSc and QUINTON DEELEY, MRCPsych

Department of Psychological Medicine, Institute of Psychiatry, London

HUGO CRITCHLEY, MRCPsych, DPhil

Functional Imaging Laboratory, Institute of Neurology, London

JAYNE HENRY, DPsych and DENE ROBERTSON, MRCPsych

Department of Psychological Medicine, Institute of Psychiatry, London

MICHAEL OWEN, FRCPsych, PhD

Department of Psychological Medicine,University of Cardiff, UK

KIERAN C. MURPHY, MRCPsych, PhD

Department of Psychiatry, Royal College of Surgeons, Dublin, Ireland

DECLAN G. MURPHY, MRCPsych, MD

Department of Psychological Medicine, Institute of Psychiatry, London.

Correspondence: Therese van Amelsvoort, Department of Psychiatry, Academic Medical Centre, Amsterdam, The Netherlands. Email: t.a.vanamelsvoort{at}amc.uva.nl

Declaration of interest None. The study was part funded by the Stanley Foundation and the Medical Research Council.

We studied the functional neuroanatomy of social behaviour in velo-cardio-facial syndrome (VCFS) using a facial emotional processing task and functional magnetic resonance imaging in adults with this syndrome and controls matched for age and IQ. The VCFS group had less activation in the right insula and frontal brain regions and more activation in occipital regions. Genetically determined abnormalities in pathways including those involved in emotional processing may underlie deficitsin social cognition in people with VCFS.