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Localisation of increased prefrontal white matter in pathological liars

Department of Psychology, University of Southern California

KATHERINE L. NARR, PhD

David Geffen School of Medicine at UCLA

TODD LENCZ, PhD

Hillside Hospital, New York

LORI LaCASSE, BA

Department of Psychology, University of Southern California

PATRICK COLLETTI, MD

Department of Radiology, University of Southern California

ARTHUR W. TOGA, PhD

David Geffen School of Medicine at UCLA, Los Angeles, California, USA

Correspondence: Dr Yaling Yang, Department of Psychology, University of Southern California, Los Angeles, CA 90089-1061, USA. Email: yalingy{at}usc.edu

Declaration of interest None. Funding detailed in Acknowledgements.

We examined white matter volumes in four prefrontal subregions using structural magnetic resonance imagingin 10 pathologicalliars, 14 antisocial controls, and 20 normal controls. Liars showed a relatively widespread increase in white matter (23–36%) in orbitofrontal, middle and inferior, but not superior, frontal gyri compared with antisocial and normal controls. This white matter increase may predispose some individuals to pathological lying.