The British Journal of Psychiatry (2007) 190: 260-265. doi: 10.1192/bjp.bp.106.025064
© 2007 The Royal College of Psychiatrists
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Effect of antidepressant therapy on executive function after stroke*

Kenji Narushima, MD, PhD, Sergio Paradiso, MD, PhD, David J. Moser, PhD, Ricardo Jorge, MD and Robert G. Robinson, MD

Department of Psychiatry, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa, USA

Correspondence: Dr Sergio Paradiso, University of Iowa Carver College of Medicine, Department of Psychiatry, 200 Hawkins Drive, W278 GH, Iowa City, IA 52242, USA. Tel: +1 (319) 384 9248; fax: +1 (319) 353 8656; email: sergio-paradiso{at}uiowa.edu

Declaration of interest None.

Funding detailed in Acknowledgements.

* Presented in part at the annual meeting of the American Neuropsychiatry Association, La Jolla, California, 18–21 February 2006.

Background Executive dysfunction is common after stroke and may impair long-term outcome. Remedies for this condition are limited.

Aims To examine the effect of antidepressants on executive function after stroke.

Method Forty-seven patients who had had a stroke during the prior 6 months received 12 weeks of antidepressant treatment in double-blind placebo-controlled fashion, followed by assessment of executive function at the end of treatment and after 2 years.

Results No significant group effect was found at the end of treatment. However, 21 months after the end of treatment the placebo group showed deterioration of executive function, whereas the active treatment group showed clear and significant improvement independent of depressive symptoms (F=12.1, d.f.=1,45, P= 0.001).

Conclusions Antidepressant treatment fosters long-term improvement of executive function following stroke. This phenomenon is consistent with a reorganisation of neuronal networks associated with prefrontal functions based on modulation of monoaminergic neurotransmission and the activity of neurotrophins.


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