HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Data supplements Submit an eLetter View responses Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Viding, E. Articles by Plomin, R. Search for Related Content PubMed Articles by Viding, E. Articles by Plomin, R.

Aetiology of the relationship between callous–unemotional traits and conduct problems in childhood

Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry and Department of Psychology, University College London, London, UK

Paul J. Frick, PhD

Department of Psychology, University of New Orleans, Louisiana, USA

Robert Plomin, PhD

Social and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK

Correspondence: Dr Essi Viding, Social Genetic and Developmental Psychiatry Centre, P080, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. Email: e.viding{at}iop.kcl.ac.uk

Declaration of interest None.

Funding detailed in Acknowledgements.

^* As some twins shared a teacher, whereas others were in different classrooms, we repeated the analyses using same and different teacher rated pairs. This did not affect the results and we therefore report data from the whole sample to increase the power of the analyses.

Background A callous and unemotional disposition is an indicator of early-onset antisocial behaviour.

Aims To investigate the extent to which genetic influences contribute to the overlap between callous-unemotional traits and conduct problems in a large population sample of 7-year-old twins.

Method Teachers provided ratings of callous-unemotional traits and conduct problems for 3434 twin pairs from the Twins Early Development Study. Model-fitting analyses were performed across the continuum of scores and at the extremes.

Results The phenotypic relationship was primarily genetically mediated, both across the continuum and at the extremes and was substantial.

Conclusions At 7 years of age, genetic influences on callous-unemotional traits overlap substantially with genetic influences on conduct problems. This combination should guide selection criteria in future molecular genetic studies.

eLetters: