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Possibilities for the prevention and treatment of cognitive impairment and dementia

Mental Health Service, St Vincent's Hospital, Darlinghurst, NSW

Ian Hickie, AM, FRANZCP, MD

Brain and Mind Research Institute, University of Sydney

Michael Breakspear, MBBS, PhD

School of Psychiatry, University of New South Wales, Randwick, NSW

Jürgen Götz, PhD

Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia

Correspondence: Dr David Burke, St Vincent's Hospital, 299 Forbes Street, Darlinghurst, NSW 2010. Australia. Tel: +612 8382 1800; fax: +612 8382 1802; email: dburke{at}stvincents.com.au

Declaration of interest None.

The human brain has a remarkable capacity for plasticity, but does it have the capacity for repair and/or regeneration? On the basis of controversial new evidence we speculate that the answer may be `yes', and suggest that clinicians should therefore approach cognitive impairment and dementia with a new, cautious optimism.

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