The British Journal of Psychiatry (2007) 190: 467-468. doi: 10.1192/bjp.bp.107.035360
© 2007 The Royal College of Psychiatrists
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Does treating depression improve survival after acute coronary syndrome?

Invited commentary on... Effects of antidepressant treatment following myocardial infarction{dagger}

ROBERT M. CARNEY, PhD and KENNETH E. FREEDLAND, PhD

Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA

Correspondence: Dr Robert M. Carney, Behavioral Medicine Center, 4625 Lindell Boulevard, Suite 420, St Louis, Missouri 63108, USA. Email: carneyr{at}bmc.wustl.edu

Declaration of interest None.

{dagger} See pp. 460–466, this issue.

Both the MIND–IT and the ENRICHD studies failed to show that medical outcomes of acute myocardial infarction can be improved by treating deperssion. However, neither study had sufficient statistical power to convincingly test this hypothesis. More effective treatments for depression will have to be developed if this hypothesis is to be tested with sufficient power in attainable samples.


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