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Influence of drug company authorship and sponsorship on drug trial outcomes

North East Wales Trust, UK

Correspondence: Dr Rob Poole, Pwll Glas Resource Centre, Pwll Glas Road, Mold, Flintshire CH7 1RA, UK. Tel: +44 (0) 1352 750252; email: eliphaz{at}doctors.org.uk

Declaration of interest T.T. has accepted sponsorship to attend conferences from Janssen-Cilag and Eli Lilly. R.P. has accepted speakers' fees from Lundbeck, Eli Lilly and Pfizer; he has also accepted sponsorship to attend conferences from Wyeth, AstraZeneca and Eli Lilly. No funding was obtained for the present study.

Studies of drug treatments are more likely to report favourable outcomes when they are funded by the pharmaceutical industry. We compared drug trials reported in three major psychiatric journals to investigate these influences. Independent studies were more likely to report negative findings than industry-funded studies. However, the involvement of a drug company employee had a much greater effect on study outcome than financial sponsorship alone.

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