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The British Journal of Psychiatry (2007) 191: 258-259. doi: 10.1192/bjp.bp.106.029017
© 2007 The Royal College of Psychiatrists
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SHORT REPORTS

Caudate volume in offspring of patients with schizophrenia

Rajaprabhakaran Rajarethinam, MD, Ameet Upadhyaya, MD, Pon Tsou, BS and Margie Upadhyaya, MD

Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan

Matcheri S. Keshavan, MD

Departments of Psychiatry, Wayne State University School of Medicine, and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

Correspondence: Dr M. S. Keshavan, Department of Psychiatry, Wayne State University School of Medicine, 4201 St Antoine Street UHC-9B, Detroit, Michigan 48201, USA. Email: mkeshava{at}med.wayne.edu

Declaration of interest None.

Caudate nuclei are smaller in drug-naive people with schizophrenia but larger in antipsychotic-treated patients. In this magnetic resonance imaging study we found volume reduction of right and left caudate by 8.9 and 8.1% respectively in 50 offspring without psychosis of patients with schizophrenia compared with 53 age- and gender-matched controls, providing new evidence that caudate volume reduction may be a trait-related abnormality in schizophrenia.




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I. Ellison-Wright, D. C. Glahn, A. R. Laird, S. M. Thelen, and E. Bullmore
The Anatomy of First-Episode and Chronic Schizophrenia: An Anatomical Likelihood Estimation Meta-Analysis
Am J Psychiatry, August 1, 2008; 165(8): 1015 - 1023.
[Abstract] [Full Text] [PDF]




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Copyright © 2007 The Royal College of Psychiatrists.