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Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan
Departments of Psychiatry, Wayne State University School of Medicine, and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Correspondence: Dr M. S. Keshavan, Department of Psychiatry, Wayne State University School of Medicine, 4201 St Antoine Street UHC-9B, Detroit, Michigan 48201, USA. Email: mkeshava{at}med.wayne.edu
Caudate nuclei are smaller in drug-naive people with schizophrenia but larger in antipsychotic-treated patients. In this magnetic resonance imaging study we found volume reduction of right and left caudate by 8.9 and 8.1% respectively in 50 offspring without psychosis of patients with schizophrenia compared with 53 age- and gender-matched controls, providing new evidence that caudate volume reduction may be a trait-related abnormality in schizophrenia.
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