The British Journal of Psychiatry (2007) 191: 282-284. doi: 10.1192/bjp.bp.107.037879
© 2007 The Royal College of Psychiatrists
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EDITORIALS

Neurokinin-1 receptor antagonists as novel antidepressants: trials and tribulations

SEPEHR HAFIZI, MSc, MRCPsych, PRAKASH CHANDRA, MBBS, PHILIP and J. COWEN, MD, FRCPsych

University Department of Psychiatry, Warneford Hospital, Oxford, UK

Correspondence: Dr Sepehr Hafizi, Neurosciences Building, University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK. Email: sepehr.hafizi{at}psych.ox.ac.uk

Declaration of interest P.J.C. has received payment for serving as a member of advisory boards of several pharmaceutical companies. Funding detailed in Acknowledgements.

Based upon animal experiments and early clinical trials, neurokinin-1 receptor antagonists showed promise as novel antidepressants. Subsequently, however, more extensive clinical trials did not reveal evidence of efficacy in depression. The development of novel antidepressants will require a better understanding of the neural basis of antidepressant action in humans.




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[Abstract] [Full Text] [PDF]