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Neurokinin-1 receptor antagonists as novel antidepressants: trials and tribulations

University Department of Psychiatry, Warneford Hospital, Oxford, UK

Correspondence: Dr Sepehr Hafizi, Neurosciences Building, University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK. Email: sepehr.hafizi{at}psych.ox.ac.uk

Declaration of interest P.J.C. has received payment for serving as a member of advisory boards of several pharmaceutical companies. Funding detailed in Acknowledgements.

Based upon animal experiments and early clinical trials, neurokinin-1 receptor antagonists showed promise as novel antidepressants. Subsequently, however, more extensive clinical trials did not reveal evidence of efficacy in depression. The development of novel antidepressants will require a better understanding of the neural basis of antidepressant action in humans.