The British Journal of Psychiatry (2008) 192: 248-257. doi: 10.1192/bjp.bp.106.029009
© 2008 The Royal College of Psychiatrists
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Review Article

Longitudinal studies of cognition in schizophrenia: meta-analysis

Andrei Szöke, MD, PhD and Anca Trandafir

INSERM U841, 94000, Créteil, France, Université Paris 12, Faculté de Médecine, IFR 10, 94000, Créteil, France, and AP-HP, Groupe Hospitalier `Chenevier-Mondor', Pôle de Psychiatrie, 94000, Créteil, France

Marie-Estelle Dupont

AP-HP, Groupe Hospitalier `Chenevier-Mondor', Pôle de Psychiatrie, 94000, Créteil, France

Alexandre Méary, MD, Franck Schürhoff, MD, PhD and Marion Leboyer, MD, PhD

INSERM U841, 94000, Créteil, France, Université Paris 12, Faculté de Médecine, IFR 10, 94000, Créteil, France, and AP-HP, Groupe Hospitalier `Chenevier-Mondor', Pôle de Psychiatrie, 94000, Créteil, France

Correspondence: Dr Andrei Szöke, Service de Psychiatrie Adulte, Hôpital Albert Chenevier, 40 rue de Mesly, 94000 Créteil, France. Email: andrei.szoke{at}ach.aphp.fr

Declaration of interest

None.

Background

A wide range of cognitive deficits have been demonstrated in schizophrenia, but their longitudinal course remains unclear.

Aims

To bring together all the available information from longitudinal studies of cognitive performance in people with schizophrenia.

Method

We carried out a meta-analysis of 53 studies. Unlike previous reviewers, we included all studies (regardless of the type of medication), analysed each variable separately and compared results with data from controls.

Results

Participants with schizophrenia showed a significant improvement in most cognitive tasks. The available data for controls showed, with one exception (the Stroop test), a similar or greater improvement. Performance in semantic verbal fluency remained stable in both individuals with schizophrenia and controls.

Conclusions

Participants with schizophrenia displayed improvement in most cognitive tasks, but practice was more likely than cognitive remediation to account for most of the improvements observed. Semantic verbal fluency may be the best candidate cognitive endophenotype.


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eLetters:

Read all eLetters

How long is longitudinal
Ahmed S huda
BJP Online, 25 Apr 2008 [Full text]
Longitudinal course of cognition in schizophrenia - the jury is still out!
Vicent Balanzá-Martínez, et al.
BJP Online, 19 Mar 2009 [Full text]
The jury is still out – waiting for new data not new analyses!
Andrei Szöke, et al.
BJP Online, 17 Apr 2009 [Full text]