The British Journal of Psychiatry (2008) 193: 126-129. doi: 10.1192/bjp.bp.107.048793
© 2008 The Royal College of Psychiatrists
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Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging

Fei Wang, MD, PhD

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, and Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA

Marcel Jackowski, PhD

Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA, and Institute of Mathematics and Statistics, University of São Paulo, Brazil

Jessica H. Kalmar, PhD, Lara G. Chepenik, MD, PhD and Karen Tie, MD

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, and Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA

Maolin Qiu, PhD

Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA

Gaolang Gong, PhD

Biomedical Engineering Department, University of Alberta, Edmonton, Canada

Brian P. Pittman, MS and Monique M. Jones, BS

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA

Maulik P. Shah, BS and Linda Spencer, BS

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, and Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA

Xenophon Papademetris, PhD and R. Todd Constable, PhD

Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA

Hilary P. Blumberg, MD

Department of Psychiatry and Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, and Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA

Correspondence: Dr Fei Wang, Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511, USA. Email: fei.wang{at}yale.edu

Declaration of interest

H.P.B. has been consultant to Pfizer Inc. and has received honoraria from Eli Lilly and Abbott Laboratories.

Background

Convergent evidence implicates white matter abnormalities in bipolar disorder. The cingulum is an important candidate structure for study in bipolar disorder as it provides substantial white matter connections within the corticolimbic neural system that subserves emotional regulation involved in the disorder.

Aims

To test the hypothesis that bipolar disorder is associated with abnormal white matter integrity in the cingulum.

Method

Fractional anisotropy in the anterior and posterior cingulum was compared between 42 participants with bipolar disorder and 42 healthy participants using diffusion tensor imaging.

Results

Fractional anisotropy was significantly decreased in the anterior cingulum in the bipolar disorder group compared with the healthy group (P=0.003); however, fractional anisotropy in the posterior cingulum did not differ significantly between groups.

Conclusions

Our findings demonstrate abnormalities in the structural integrity of the anterior cingulum in bipolar disorder. They extend evidence that supports involvement of the neural system comprising the anterior cingulate cortex and its corticolimbic gray matter connection sites in bipolar disorder to implicate abnormalities in the white matter connections within the system provided by the cingulum.


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