The British Journal of Psychiatry (2008) 193: 338-339. doi: 10.1192/bjp.bp.107.043497
© 2008 The Royal College of Psychiatrists
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SHORT REPORTS

Serum levels of P-selectin in men with high-functioning autism

Y. Iwata, MD, PhD, K. J. Tsuchiya, MD, PhD, S. Mikawa, PhD, K. Nakamura, MD, PhD, Y. Takai, MEd, S. Suda, MD, PhD, Y. Sekine, MD, PhD, K. Suzuki, MD, PhD, M. Kawai, MD, PhD and G. Sugihara, MD, PhD

Hamamatsu University School of Medicine, Shizuoka

H. Matsuzaki, MD, PhD

Osaka-Hamamatsu Joint Research Center for Child Mental Development, Osaka University, Osaka

K. Hashimoto, PhD

Chiba University Center for Forensic Mental Health, Chiba

M. Tsujii, PhD

Faculty of Sociology, Chukyo University, Aichi

T. Sugiyama, MD, PhD

Aichi Children's Health and Medical Center, Aichi

N. Takei, MD, PhD, MSc

Hamamatsu University School of Medicine, Shizuoka, Japan, and Institute of Psychiatry, London, UK

N. Mori, MD, PhD

Hamamatsu University School of Medicine, Shizuoka, Japan

Correspondence: Professor Nori Takei, The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan. Email: ntakei{at}hama-med.ac.jp

Declaration of interest

None. Funding detailed in Acknowledgements.

Immune dysfunction has been proposed as a mechanism for the pathophysiology of autistic-spectrum disorders. The selectin family of adhesion molecules plays a prominent role in immune/inflammatory responses. We determined the serum levels of three types of soluble-form selectin (sP, sL and sE) in 15 men with high-functioning autism and 22 age-matched healthy controls by enzyme-linked immunosorbent assay. Levels of sP-selectin and sL-selectin were significantly lower in patients than in controls. Furthermore, sP-selectin levels were negatively correlated with impaired social development during early childhood.




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