The British Journal of Psychiatry (2008) 193: 424-425. doi: 10.1192/bjp.bp.107.040501
© 2008 The Royal College of Psychiatrists
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SHORT REPORTS

Time course of regional brain activation associated with onset of auditory/verbal hallucinations

Ralph E. Hoffman, MD

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut

Adam W. Anderson, PhD

Department of Biomedical Engineering and Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee

Maxine Varanko, PsyD

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut

John C. Gore, PhD

Department of Biomedical Engineering and Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee

Michelle Hampson, PhD

Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA

Correspondence: Dr Ralph Hoffman, Yale–New Haven Psychiatric Hospital, 184 Liberty Street LV108, New Haven, CT 06519, USA. Email: ralph.hoffman{at}yale.edu

Declaration of interest

None. Funding detailed in Acknowledgements.

The time course of brain activation prior to onset of auditory/verbal hallucinations was characterised using functional magnetic resonance imaging in six dextral patients with schizophrenia. Composite maps of pre-hallucination periods revealed activation in the left anterior insula and in the right middle temporal gyrus, partially replicating two previous case reports, as well as deactivation in the anterior cingulate and parahippocampal gyri. These findings may reflect brain events that trigger or increase vulnerability to auditory/verbal hallucinations.


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