The British Journal of Psychiatry (2009) 194: 1-3. doi: 10.1192/bjp.bp.108.054767
© 2009 The Royal College of Psychiatrists
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EDITORIAL

Antidepressants on trial: how valid is the evidence?

Gordon Parker

School of Psychiatry, University of New South Wales, Black Dog Institute, Randwick 2031, Sydney, Australia. Email: g.parker{at}unsw.edu.au

Declaration of interest

G.P. serves on several advisory boards for antidepressant drugs, and has chaired and spoken at meetings convened by pharmaceutical companies.

A recent meta-analysis concluded that newer antidepressant drugs are equivalent to or no better than placebos, a conclusion at some variance with their commonly judged clinical effectiveness. The ‘disconnect’ betweenrandomised controlled trials and clinical practice would benefit from dissection of contributing factors, and redressing limitations to current trial procedures.


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