The British Journal of Psychiatry (2009) 194: 373-374. doi: 10.1192/bjp.bp.108.055459
© 2009 The Royal College of Psychiatrists
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SHORT REPORTS

Using the Stroop task to investigate the neural correlates of symptom change in schizophrenia

Lydia Krabbendam, PhD

Institute of Psychiatry, King’s College London, UK and School for Mental Health and Neuroscience, University of Maastricht, The Netherlands

Owen O’Daly, BSc, MSc and Lucy A. Morley, MBBS, PhD, MRCPsych

Institute of Psychiatry, King’s College London, UK

Jim van Os, MD, PhD

Institute of Psychiatry, King’s College London, UK and School for Mental Health and Neuroscience, University of Maastricht, The Netherlands

Robin M. Murray, MD, DSc, FRCPsych

Institute of Psychiatry, King’s College London, UK

Sukhwinder S. Shergill, MBBS, PhD, FRCPsych

Institute of Psychiatry, King’s College London, and Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, UK

Correspondence: Dr Lydia Krabbendam, Department of Psychiatry and Neuropsychology, Maastricht University, PO BOX 616 (location VIJV), 6200 MD Maastricht, The Netherlands. Email: l.krabbendam{at}sp.unimaas.nl

Declaration of interest

None.

Funding

L.K. was funded by a VIDI Grant from the Netherlands Organisation for Scientific Research (NWO); S.S.S. was funded by the Wellcome Trust; and L.A.M. and O.O’D. were funded by the Psychiatry Research Trust.

This study examined brain activation during a cognitive inhibition task in patients with schizophrenia following changes in their positive symptoms. A Stroop task was used during functional magnetic resonance imaging in 11 patients with schizophrenia (patient group) and 9 healthy volunteers (control group). At baseline, the patient group showed significantly attenuated activation within the anterior cingulate gyrus, left pre-/postcentral gyrus and inferior frontal junction. At follow-up, there was a significant increase in activation in the left inferior frontal junction associated with a decrease in positive symptoms, suggesting this region plays a role in the development of these symptoms.




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Issues involved in using the Stroop task in schizophrenia
Preeti Parakh
BJP Online, 14 Sep 2009 [Full text]