Journal of Mental Science (1930) 76: 772-779. doi: 10.1192/bjp.76.315.772
© 1930 The Royal College of Psychiatrists
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The Protein Partition of the Serum in General Paralysis of the Insane, with Special Reference to Treatment

W. Ogden, M.R.C.S., L.R.C.P., D.P.M.

From the Central Pathological Laboratory, Maudsley Hospital

ABSTRACT

1. In untreated general paralysis there is an apparent excess of serum protein with corresponding globulin increase.
2. Following malarial therapy in general paralysis there is no discernible increase of serum protein, but the albumen-globulin balance is disturbed, with an apparent increase of globulin.
3. In general paralysis pyrexial therapy induced by sulfosin appears to affect the serum protein in exactly the same way as malaria; the same sulfosin treatment in dementia præcox is not associated with an increase of total protein, but there is an apparent increase in the globulin fraction.
4. Tryparsamide treatment in general paralysis has no obvious effect on the total serum protein or the albumen-globulin partition.
5. There is no apparent relation between any altered state of the serum protein and the intensity of the Wassermann reaction.