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Spontaneous Hypoglycaemia and Diabetes Mellitus Associated with the Insulin Coma Therapy of Schizophrenia

From the Department of Clinical Research, Crichton Royal, Dumfries

ABSTRACT

Two unusual complications of the insulin coma therapy of schizophrenia are reported.

The first patient had attacks of spontaneous hypoglycaemia over a period despite the withholding of insulin. Blood glucose studies are recorded. They showed a gradual return to normal over a period of four weeks.

The second patient developed diabetes mellitus within about a month of completing a course of insulin coma therapy. It is suggested that this patient was genetically predisposed to diabetes mellitus.

Comment is made on the rarity of reports in the literature of the occurrence of schizophrenia and diabetes mellitus in the same patient.

Received for publication October 6, 1949.