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Clinical and Biochemical Investigations in a Manic-Depressive with Short Cycles

Bristol Mental Hospital, Fishponds, Bristol

ABSTRACT

Clinical and biochemical investigations were carried out on a 44-year-old patient who for five years had short manic-depressive cycles. The biochemical results, specially considered in this paper, were retention of salt and water in the depression as compared with the manic phase. There was a concurrent tendency to prolonged sleep in the depression and sleeplessness during mania. This association was still more striking in a previous case, where the normal diurnal cycle of sleep-wakefulness and water and salt excretion was replaced by the manic-depressive cycle. A disturbance of a regulatory diencephalic mechanism was considered possible—a view which seemed to be supported by general features in the clinical picture of the two cases.

Received for publication October 1, 1949.